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<h6 style="text-align:center; margin:10px 10px 10px 10px;">Instructions of How to Define Sample Sizes</h6>
<p style="text-align:justify; margin:10px 10px 10px 10px; line-height:1.5">In the <b>"Controls"</b> field, put the total number (n) of individuals from your control sample, and in the <b>"Patients"</b> field, put the total number (n) of your patients sample.</p><p style="text-align:justify; margin:10px 10px 10px 10px; line-height:1.5">If your disease association study compares different disease conditions, or if your control sample has specific characteristics (e.g. all men, all women, all children, etc.), use the <b>"Special Controls"</b> field.</p>
<p style="text-align:justify; margin:10px 10px 10px 10px; line-height:1.5">If you are going to use <b>"Special Controls"</b> field, please also specify the "special" characteristic of your sample in the <strong>"Extra Notes"</strong> field.</p>
<p class="important" style="text-align:justify; margin:10px 10px 10px 10px; line-height:1.5"><strong>Important!</strong></p>
<p style="text-align:justify; margin:10px 10px 10px 10px; line-height:1.5">Insert a <span class="important">&quot;0&quot;</span> (zero) in the field that does not apply to your control sample (<strong>&quot;Controls&quot; or &quot;Special Controls&quot;)</strong>, e.g. if your control sample is defined as &quot;Controls&quot;, put &quot;0&quot; in &quot;Special Controls&quot; field, and vice versa.</p>

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